New research reveals that patients who come off new weight-loss injections like Mounjaro or Wegovy may regain lost weight far faster than those who end traditional lifestyle plans.
Findings released in a major health publication points out that while obese people frequently drop a large proportion of their body weight while on the medication, the weight comes back at an estimated rate of 0.8 kg per month after stopping.
"Individuals purchasing such treatments should be informed of the potential of rapid weight regain when the medication ends," cautioned researcher Dr. Susan Jebb.
Such speed of regain suggests a return to original weight within about a year and a half.
Analyzing Therapies
The study, which examined 37 of trials involving thousands of participants, contrasted the effects of GLP-1 agonists with other pills.
The team note that individuals who lose weight through lifestyle changes alone usually experience a more gradual creep back—approximately 100 grams monthly—after stopping.
The Reason for the Quick Regain
Doctors suggest the way of the jabs is key to understanding the accelerated rebound.
The injections mimic a natural hormone called glucagon-like peptide-1, which helps regulate hunger.
"Long-term administration of the hormone levels far above than normal might result in the system to generate a reduced amount of its endogenous hormone, and may also diminish sensitivity to its effects," noted Dr. Adam Collins, a nutrition researcher.
"Withdrawal of this hormone supplement means appetite is no longer kept in check, making excessive eating far more likely."
An Ongoing Issue?
The NHS recommend the jabs for individuals with obesity-related medical conditions, accompanied by recommended lifestyle changes.
A number of clinicians contend that, due to the likelihood of relapse, the therapy is often life-long.
This view is echoed by pharmaceutical companies, who say that the results "underscore the persistent character of excess weight," similar to managing diseases like diabetes.
User Accounts
People who have come off the medication report a intense resurgence of hunger.
"It was like something flipping and you become ravenous," said an individual.
This challenge is exacerbated if users have not established permanent dietary or behavioural changes during treatment.
Significant Interest
Figures indicate that a significant number of people in the UK have tried weight-loss jabs in the last 12 months, with demand being substantial.
- Adoption is greater among women than men.
- The 40s and 50s age group shows the greatest level of interest.
- A large proportion obtain the medications through private prescriptions rather than the NHS.
Finally, clinicians stress that while the jabs are potent tools for shedding pounds, they are not a standalone fix and maintained weight loss likely depends on combined behavioural changes.
